Millions of people are vulnerable to HIV infection, and AIDS remains the leading cause of death among women of reproductive age and young adolescents. Stigma and discrimination continue to impede the realization of people’s rights, including access to essential information and services to prevent and treat HIV. Ending the AIDS epidemic requires long-term investments. Sexual and reproductive health and rights, indeed all human rights, are essential for realizing this vision. And given their higher risk of HIV infection, youth and key populations require focused support. UNFPA’s approach to HIV is based around three strategies: promoting human rights and reducing inequalities, integrating HIV responses into sexual and reproductive health care, and preventing sexual transmission of HIV.